(Chipingamupinyi cheRopa-uropi, BBB)
Ropa-brain barriers ndeimwe yenzira dzakakosha dzekuzvidzivirira muvanhu.Inoumbwa neuropi capillary endothelial masero, glial masero, uye choroid plexus, inobvumira chete chaiwo marudzi emamorekuru kubva muropa kupinda muuropi neurons nemamwe masero akatenderedza, uye anogona kudzivirira zvakasiyana-siyana zvinokuvadza kuti zvipinde muuropi tishu.Uropi, sechakavanzika uye chakakosha chikamu chemuviri wemunhu, chinotonga akawanda akakosha mabasa.Iyo yeropa-uropi chipingamupinyi chinogona kuvharira zvinhu zvinokuvadza muropa uye kudzivirira kuchengetedzwa kwehuropi tishu.
Chirwere cheAlzheimer, AD
Chirwere cheAlzheimer (AD) chirwere chinofambira mberi neurodegenerative chine kutanga kusinganzwisisike.Muchiito chekiriniki, dementia yakazara inoratidzwa nekukanganisika kwendangariro, aphasia, aphasia, kurasikirwa nekuzivikanwa, kukanganiswa kweunyanzvi hwekuona uye nzvimbo, kusashanda zvakanaka kwevakuru, uye hunhu uye kuchinja kwemaitiro.Iyo etiology haisati yazivikanwa.Premature dementia inoreva vanhu vanotanga zviratidzo vasati vava nemakore makumi matanhatu nemashanu;Vanhu vanokura dementia mushure memakore makumi matanhatu nemashanu vanonzi senile dementia.Chiitiko chechirwere cheAlzheimer (AD) chinowanzobatanidzwa ne β- Amyloid protein (A β) Kuunganidza uye Tau protein entanglement yakabatanidzwa, uye tsvakurudzo yakawanda inonyora zvishoma nezvishoma neuroinflammation sechimwe chezvikonzero zvinokonzera kuitika kweAD.
Quote: Chii chinonzi Alzheimer's?Tarisa ruzivo urwu.People's Daily Online.2023-09-20
Cherechedza kuti kune rudzi rwebhakitiriya runogona kupinda mukati meropa-brain barrier
Nguva pfupi yadarika, vaongorori veBaylor College yeMishonga muUnited States vakaburitsa bepa rekutsvagisa rine musoro unoti: Toll like receptor 4 neCD11b inoratidzwa pamicroglia coordinate erasure yeCandida albicans cerebral mycosis mujenari diki reMasero.
Takawana fungus inonzi Candida albicans inogona kupinda muuropi kuburikidza neropa.Sekutaura kunoita chirevo chakakurumbira, "Kurova gumbo rechirema kunogona kukonzera chirwere cheAlzheimer sekuchinja."Muchidzidzo ichi, takazivisa zvakare mamorekuru maitiro ayo Candida albicans anopwanya nemuropa-brain barriers uye achipinda muuropi, zvichitungamira kuchirwere cheAlzheimer sekuchinja.
Candida albicans inopinda sei muuropi?"Takaona kuti Candida albicans inogadzira enzyme inonzi secreted aspartate protease (Saps), iyo inokanganisa ropa-brain barrier, ichibvumira fungi kupinda muuropi uye kukonzera kukanganisa," akadaro Dr. Yifan Wu, postdoctoral pediatric science anoshanda paCorry. Murabhoritari.
Candida albicans
Candida albicans (zita resainzi: Candida albicans) mbiriso inogona kukonzeresa hutachiona.Inowanzo kuwanikwa munharaunda yebhakitiriya yehutano hwevanhu uye urogenital turakiti.Vanenge 40% kusvika 60% yevakuru vane hutano vane Candida albicans mumaturakiti avo emuromo uye ekugaya.Candida albicans inowanzogara pamwe chete nemuviri wemunhu, asi inogona kukura panguva yekushomeka kwekudzivirira uye kukonzera candidiasis.Ndiro rinowanzo zivikanwa pathogenic bhakitiriya muCandida genus
Maererano neongororo yakaitwa muCell Reports, fungi dzatisingawanzo tarisisa zvakanyanya dzinogona kunge dziri imwe yezvikonzero zvechirwere cheAlzheimer.Vatsvagiri kubva kuBaylor Chikoro cheMishonga uye masangano anodyidzana vakawana kuburikidza nemhando dzemhuka kuti Candida albicans inopinda sei muuropi uye nemabatiro aanoita nzira mbiri dzakazvimiririra mumaseru ehuropi anosimudzira kuburitswa kwayo (izvo zvakakosha pakunzwisisa kukura kwechirwere cheAlzheimer), uye vakagadzira. β Amyloid protein (A β） Peptides (chepfu mapuroteni zvidimbu zveamyloid protein) anoonekwa semusimboti wekukura kwechirwere cheAlzheimer.
Dr. David Corry vakadaro.David Corry ndiye Sachigaro wePathology paFulbright Foundation uye purofesa wezvirwere, immunology, uye mushonga paBaylor University.Iye zvakare inhengo yeBaylor L. Duncan Comprehensive Cancer Center.Muna 2019, takaona kuti maCandida albicans akanyatsopinda muuropi uye akagadzira shanduko dzakafanana nechirwere cheAlzheimer.Kuzvimba kunokonzerwa neCandida albicans kazhinji kunoperekedza
A β Chikonzero chekugadzirwa kwemaamyloid semapeptides ndechekuti Sap inogona hydrolyze amyloid precursor proteins (APPs).
Nekudaro, aya peptide zvakare anokwezva kutarisisa kwehuropi immune masero - microglia, iyo yakakosha kune kunotevera kucheneswa kweCandida albicans nehuropi pachahwo.Pamusoro pezvo, chepfu yeCandidalysin inogadzirwa naCandida albicans inomisa microglia neimwe nzira.Kana nzira iyi ikavhiringidzwa, fungi muuropi haigoni kubviswa.
Vatsvagiri vanonongedza kuti basa iri rinogona kuve rakakosha pikicha yekunzwisisa kuitika kwechirwere cheAlzheimer.Zvidzidzo zvakapfuura zvakaratidza kuti maprotease ari muuropi ane chekuita nekuparara kweapps uye anobatsira kuA β Kuunganidzwa kweiyo kwakaisa hwaro.Uye zvino zvinogona kusimbiswa kuti iyi exogenous protease kubva kufungi inogonawo kukonzera A β Peptide sekugadzirwa.
Vatsvagiri vanoti kumwe kuongororwa kwebasa reCandida albicans mukukura kwechirwere cheAlzheimer kunodiwa mune ramangwana, izvo zvinogona zvakare kutungamira kune matsva ekurapa maitiro eAD.
Reference materials:
[1] Yifan Wu et al, Toll like receiver 4 uye CD11b inoratidzwa pa microglia coordinate erasure ye Candida albicans cerebral mycosis, Cell Reports (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Brain inoshanda utachiona zvigadzirwa Chirwere cheAlzheimer senge shanduko, taura chidzidzo chitsva Yakadzorerwa Gumiguru 17, 2023 kubva https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Nguva yekutumira: Zvita-22-2023